Evaluation of Coagulation Disorder in Patients with Liver Disease in Bangladesh
نویسندگان
چکیده
In liver disorder, prothrombin time (PT) is elevated, and fibrinogen level decreased which are considered predictors of increased bleeding risk. We aimed at determining whether increased PT and fibrinogen value reflect the haemostatic potential and bleeding risk in patients with liver disorder. The study comprises a total of 135 subjects including patients with liver disorder (n=75) and healthy volunteer (n=60) matched by age and sex. The PT was measured by STart 4 haemostasis analyzer and fibrinogen was measured by ELISA based method. The PT was significantly (p<0.001) increased in patients with liver disorder compared to the controls. On the other hand, the fibrinogen level was significantly decreased (p<0.001) in patients with liver disorder. There was a negative correlation (r = -0.6; p<0.001) of fibrinogen with PT. Coagulation abnormalities were profound in liver disorder. Thus PT and fibrinogen level may be used as a useful tool for diagnosis and treatment of liver disorder.
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